Instructor: Peter Jonas
Teaching Assistants: Claudia Espinoza, Jose Guzman
The goal of this course is to give an overview over molecular and cellular neuroscience and to discuss certain interesting aspects in detail at a quantitative level. The course will cover the following topics
Membranes and membrane proteins: Lipids bilayers, ion channels, receptors for various transmitters and signaling substances, and ion pumps.
Axons and excitable membranes: Ionic mechanisms of resting potential and action potential, molecular properties of voltage-gated sodium and potassium channels, and mechanisms underlying speed of propagation of action potentials.
Synapses and exocytosis: Mechanisms of transmitter release, mechanisms of postsynaptic receptor activation, comparison of synaptic transmission at the neuromuscular junction and at central synapses, and functional properties of electrical synapses.
Dendrites: Cable properties of dendrites, integration of excitatory and inhibitory potentials (EPSPs and IPSPs), active properties of dendrites, action potential backpropagation into the dendritic tree.
Building quantitative molecular and cellular models: Synapse models, single neuron models, and neuronal network models, usage of different computational platforms (Neuron, Mathematica, and others).
To facilitate understanding, the material is systematically presented in a bottom-up sequence. The goal is to obtain a quantitative understanding of molecular and cellular aspects of neuroscience.
The course is obligatory for students considering a PhD in any of the neuroscience groups. The course may be also interesting for cell biologists and computer scientists.
3 ECTS points
|November 23, 25||Membranes and membrane proteins||Mondi 1||8:45–10:00|
|November 30, December 2||Axons and excitable membranes||Mondi 1||8:45–10:00|
|November 30||Recitation||Mondi 1||11:45–12:35|
|December 7, 9||Peripheral synapses and exocytosis||Mondi 1||8:45–10:00|
|December 7||Recitation||Mondi 1||11:45–12:35|
|December 14, 16||Central synapses and dendrites||Mondi 1||8:45–10:00|
|December 14||Recitation||Mondi 1||11:45–12:35|
|December 21-January 6||Christmas break|
|January 11, 13||Modeling receptors, synapses||Mondi 1, Mondi 3 (January 11)||8:45–10:00|
|January 11||Recitation||Mondi 1||11:45–12:35|
|January 18, 20||Modeling neurons and networks; Exam week||Mondi 1||8:45–10:00|
|January 18||Recitation||Mondi 1||11:45–12:35|
|Lecture November 23, 25||n/a|
|Lecture November 30||n/a|
|Lecture December 2||n/a|
|Lecture December 7 & 9||n/a|
|Lecture December 14 & 16||n/a|
|Lecture January 11 & 13||n/a|
|Lecture January 18 & 20||n/a|
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