IST Austria Courses
IST Austria logo

Quantitative Approaches to Evolution

Instructor: Nick Barton

Teaching Assistant: Enikő Szép

Description

 

 An introduction to quantitative models of evolution, including both the historical development and current open questions. Each week, there will be an introductory lecture, followed by a discussion of classic papers. There will also be homework problems. 

 

  Historical introduction: Basics principles of evolution; origins of population genetics

  Quantitative genetics: Inheritance of quantitative traits; selection, mutation and drift

  Neutral theory of molecular evolution: Random drift of allele frequencies; the coalescent

  Selection: Basics of selection; directional, purifying and balancing selection

  Selection and drift: Fixation probability, selective sweeps

  Gene flow and spatial variation: clines, isolation by distance

 

Requirements/Exams

homeworks

 


Credits

3 ECTS 

 

Schedule

Date Topic Location
     
Tuesday, 1. March History Mondi 3
Thursday, 3. March Selection Mondi 3
Tuesday, 8. March Selection Mondi 3
Thursday, 10. March Neutral theory Mondi 3
Tuesday, 15. March Neutral theory Mondi 3
Thursday, 17. March Neutral theory Mondi 3
Tuesday, 5. April Neutral theory Mondi 3
Thursday, 7. April Selection and drift Mondi 3
Tuesday, 12. April Selection and drift Mondi 3
Thursday, 14. April Quantitative genetics Mondi 3
Tuesday, 19. April Quantitative genetics Mondi 3
Thursday, 21. April Spatial models Mondi 3
Tuesday, 26. April Spatial models Mondi 3

Homework

File Due Date Answers
Homework 1 14. March Answers
Homework 2 - Answers
Homework 3 - Answers
Homework 4 - Answers

Additional Downloads

To take a look at the additional Downloads, please click here. (you must be logged in!)

Intro to Mathematica

Background reading 1: Maynard Smith, J.; Haigh, J: The hitch-hiking effect of a favourable gene, 1974

Gadgets in R: allele frequencies, coalescent process, how to use them

Some solutions for the allele frequency notebook

Review on the coalescent theory: Hudson, 1991 

3 fun papers to read:

Fisher, Fisher, Robertson

Books to read:

Wakely: Coalescent Theory: An Introduction

Charlesworth, Charlesworth: Elements of Evolutionary Genetics